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STAMBP 抗体 (C-Term)

This anti-STAMBP antibody is a 兔 多克隆 antibody detecting STAMBP in WB 和 ELISA. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6265307
发货至: 中国

Quick Overview for STAMBP 抗体 (C-Term) (ABIN6265307)

抗原

See all STAMBP 抗体
STAMBP (STAM Binding Protein (STAMBP))

适用

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人, 小鼠, 大鼠

宿主

  • 59
  • 4

克隆类型

  • 59
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多克隆

标记

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This STAMBP antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA
  • 抗原表位

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    C-Term

    特异性

    STAMBP Antibody detects endogenous levels of total STAMBP.

    预测反应

    Pig,Bovine,Horse,Sheep,Rabbit,Xenopus

    纯化方法

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    免疫原

    A synthesized peptide derived from human STAMBP, corresponding to a region within C-terminal amino acids.

    亚型

    IgG
  • 应用备注

    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C. Stable for 12 months from date of receipt.

    有效期

    12 months
  • 抗原

    STAMBP (STAM Binding Protein (STAMBP))

    别名

    STAMBP

    背景

    Description: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.

    Gene: STAMBP

    分子量

    50 kDa

    基因ID

    10617

    UniProt

    O95630
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