电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

SRPK2 抗体

This anti-SRPK2 antibody is a 兔 多克隆 antibody detecting SRPK2 in WB, ELISA 和 IHC. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6265291
发货至: 中国

Quick Overview for SRPK2 抗体 (ABIN6265291)

抗原

See all SRPK2 抗体
SRPK2 (SFRS Protein Kinase 2 (SRPK2))

适用

  • 39
  • 23
  • 1
  • 1
  • 1
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 37
  • 2

克隆类型

  • 39
多克隆

标记

  • 17
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This SRPK2 antibody is un-conjugated

应用范围

  • 20
  • 15
  • 14
  • 14
  • 13
  • 5
  • 5
  • 4
  • 3
  • 3
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 特异性

    SRPK2 Antibody detects endogenous levels of total SRPK2

    交叉反应

    人, 小鼠, 大鼠

    纯化方法

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    免疫原

    A synthesized peptide derived from human SRPK2

    亚型

    IgG
  • 应用备注

    WB 1:1000-3000 IHC 1:200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C.Stable for 12 months from date of receipt

    有效期

    12 months
  • 抗原

    SRPK2 (SFRS Protein Kinase 2 (SRPK2))

    别名

    SRPK2

    背景

    Description: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.

    Gene: SRPK2

    分子量

    78 kDa

    基因ID

    6733

    UniProt

    P78362

    途径

    Ribonucleoprotein Complex Subunit Organization
You are here:
Chat with us!