SMN1 抗体
Quick Overview for SMN1 抗体 (ABIN6265189)
抗原
See all SMN1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- SMN1 Antibody detects endogenous levels of total SMN1
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human SMN1
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亚型
- IgG
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anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibody
SMN1 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 5H1 unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人, 猴 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 80-150) antibodySMN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (N-Term) antibodySMN1 适用: 人, 小鼠, 大鼠, 犬, Pig, 兔, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 2-294) antibodySMN1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 3-194) antibodySMN1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人, 小鼠, 非洲爪蟾 WB, ELISA, IF, IP, ICC, IHC (p), FACS 宿主: 小鼠 Monoclonal 2B1 unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 1-140) antibodySMN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 22-52), (N-Term) antibodySMN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))
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别名
- SMN1
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背景
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Description: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
Gene: SMN1, SMN2
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分子量
- 32 kDa
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基因ID
- 66, 066, 607
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UniProt
- Q16637
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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