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- 抗原 See all SLAMF1 抗体
- SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1))
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抗原表位
- C-Term
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SLAMF1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- SLAM / CD150 Antibody detects endogenous levels of total SLAM / CD150.
- 预测反应
- Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human SLAM / CD150, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product SLAMF1 Primary Antibody
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anti-Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) (AA 19-236) antibody
SLAMF1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) (Tyr1096) antibodySLAMF1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) (AA 231-335) antibodySLAMF1 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) (AA 69-204) antibodySLAMF1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) antibodySLAMF1 适用: 人 FACS, IP, ICC 宿主: 小鼠 Monoclonal SLAM-4 unconjugated
anti-Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) antibody (FITC)SLAMF1 适用: 人 FACS 宿主: 小鼠 Monoclonal SLAM-4 FITC
anti-Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) (pTyr281) antibodySLAMF1 适用: 人 ELISA, DB 宿主: 兔 Polyclonal unconjugated
anti-Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) antibody (APC)SLAMF1 适用: 人 FACS 宿主: 小鼠 Monoclonal SLAM-4 APC
anti-Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) antibody (PE)SLAMF1 适用: 人 FACS 宿主: 小鼠 Monoclonal SLAM-4 PE
anti-Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) (AA 21-237) antibodySLAMF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1))
- 别名
- SLAMF1 (SLAMF1 产品)
- 别名
- CD150 antibody, SLAM antibody, SLAMF1 antibody, 4933415F16 antibody, AA177906 antibody, CDw150 antibody, ESTM51 antibody, IPO-3 antibody, Slam antibody, RGD1560634 antibody, signaling lymphocytic activation molecule family member 1 antibody, SLAMF1 antibody, Slamf1 antibody
- 背景
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Description: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4+ cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4-/CD8- T-cells (By similarity). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102). May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity). Involved in innate immune response against Gram-negative bacteria in macrophages, probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns3P and NOX2 activity in the phagosomes (PubMed:20818396).
Gene: SLAMF1
- 分子量
- 70kDa
- 基因ID
- 6504
- UniProt
- Q13291
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