SKP2 抗体 (C-Term)
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北京 101111
Quick Overview for SKP2 抗体 (C-Term) (ABIN6265105)
抗原
See all SKP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- SKP2/p45 Antibody detects endogenous levels of total SKP2/p45.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human SKP2/p45, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-S-Phase Kinase-Associated Protein 2 (SKP2) (AA 351-424) antibody
SKP2 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-S-Phase Kinase-Associated Protein 2 (SKP2) (AA 1-100) antibodySKP2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-S-Phase Kinase-Associated Protein 2 (SKP2) antibodySKP2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-S-Phase Kinase-Associated Protein 2 (SKP2) (AA 221-425) antibodySKP2 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-S-Phase Kinase-Associated Protein 2 (SKP2) (AA 43-397) antibodySKP2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-S-Phase Kinase-Associated Protein 2 (SKP2) (AA 1-424) antibodySKP2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-S-Phase Kinase-Associated Protein 2 (SKP2) antibodySKP2 适用: 人 IHC, ELISA, IF 宿主: 兔 Monoclonal 6D4 unconjugated Recombinant Antibody
anti-S-Phase Kinase-Associated Protein 2 (SKP2) antibodySKP2 适用: 人 ELISA, IF, FACS 宿主: 兔 Monoclonal 3C11 unconjugated Recombinant Antibody
anti-S-Phase Kinase-Associated Protein 2 (SKP2) (AA 1-424) antibodySKP2 适用: 人 WB, PLA 宿主: 小鼠 Polyclonal unconjugated
anti-S-Phase Kinase-Associated Protein 2 (SKP2) antibodySKP2 适用: 人 WB, IHC, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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: "S-phase kinase-associated protein 2 impairs the inhibitory effects of miR-1236-3p on bladder tumors." in: American journal of translational research, Vol. 10, Issue 3, pp. 731-743, (2018) (PubMed).
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: "S-phase kinase-associated protein 2 impairs the inhibitory effects of miR-1236-3p on bladder tumors." in: American journal of translational research, Vol. 10, Issue 3, pp. 731-743, (2018) (PubMed).
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- SKP2 (S-Phase Kinase-Associated Protein 2 (SKP2))
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别名
- SKP2
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背景
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Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
Gene: SKP2
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分子量
- 47kDa
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基因ID
- 6502
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UniProt
- Q13309
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途径
- Mitotic G1-G1/S Phases
抗原
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