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SETMAR 抗体 (N-Term)

This anti-SETMAR antibody is a 兔 多克隆 antibody detecting SETMAR in ELISA 和 WB. Suitable for 人.
产品编号 ABIN6265021
发货至: 中国

Quick Overview for SETMAR 抗体 (N-Term) (ABIN6265021)

抗原

See all SETMAR 抗体
SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))

适用

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宿主

  • 17
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克隆类型

  • 20
多克隆

标记

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This SETMAR antibody is un-conjugated

应用范围

  • 8
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ELISA, Western Blotting (WB)
  • 抗原表位

    • 3
    • 2
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    N-Term

    特异性

    SETMAR Antibody detects endogenous levels of total SETMAR.

    预测反应

    Bovine,Dog

    纯化方法

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    免疫原

    A synthesized peptide derived from human SETMAR, corresponding to a region within N-terminal amino acids.

    亚型

    IgG
  • 应用备注

    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C. Stable for 12 months from date of receipt.

    有效期

    12 months
  • 抗原

    SETMAR (SET Domain and Mariner Transposase Fusion Gene (SETMAR))

    别名

    SETMAR

    背景

    Description: Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750).

    Gene: SETMAR

    分子量

    78 kDa

    基因ID

    6419

    UniProt

    Q53H47

    途径

    Positive Regulation of Response to DNA Damage Stimulus
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