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CXCL12 抗体 (C-Term)

Name: CXCL12 抗体 (C-Term)
SKU: ABIN6264954
Availability: OutOfStock

This anti-CXCL12 antibody is a 兔多克隆 antibody detecting CXCL12 in WB, IHC 和 ELISA. Suitable for 人, 小鼠和大鼠. This Primary Antibody has been cited in 1 publication.

Western blot analysis of SDF 1 expression in HepG2 cells,The lane on the left is treated with the antigen-specific peptide. (CXCL12 抗体 (C-Term))

ABIN6268714 at 1/100 staining human colon tissue sections by IHC-P. (CXCL12 抗体 (C-Term))

IHC

2 images

(1 reference)

产品编号 ABIN6264954

发货至: 中国

Datasheet as PDF

Quick Overview for CXCL12 抗体 (C-Term) (ABIN6264954)

抗原

See all CXCL12 抗体

CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This CXCL12 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Discover our top product CXCL12 Primary Antibody

抗原表位
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1
C-Term

特异性

SDF 1 Antibody detects endogenous levels of total SDF 1.

预测反应

Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human SDF 1, corresponding to a region within C-terminal amino acids.

亚型

IgG
anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibody
CXCL12 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 23-89) antibody
CXCL12 适用: 人 WB, IHC, ICC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 31-80) antibody
CXCL12 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 22-89) antibody
CXCL12 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibody
CXCL12 适用: 人, 小鼠, 犬, 小鸡, 非洲爪蟾, Bat, 豚鼠, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibody
CXCL12 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 24-70) antibody
CXCL12 适用: 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (C-Term) antibody
CXCL12 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) (AA 23-89) antibody
CXCL12 适用: 人 WB 宿主: 小鼠 Monoclonal C3 unconjugated

anti-Chemokine (C-X-C Motif) Ligand 12 (CXCL12) antibody
CXCL12 适用: 人 WB, IHC, ELISA, IHC (p), Neut 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
Wang, Wang, Gao, Zhang, Lou, Jin, Chen, Lei, Xu, Mao: "Highly efficient local delivery of endothelial progenitor cells significantly potentiates angiogenesis and full-thickness wound healing." in: Acta biomaterialia, Vol. 69, pp. 156-169, (2018) (PubMed).
抗原

CXCL12 (Chemokine (C-X-C Motif) Ligand 12 (CXCL12))

别名

CXCL12

背景

Description: Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development, required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity).
Gene: CXCL12

分子量

10 kDa

基因ID

6387

UniProt

P48061

途径

Regulation of Cell Size, CXCR4-mediated Signaling Events, Negative Regulation of intrinsic apoptotic Signaling