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- 抗原 See all PTPN2 抗体
- PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTPN2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 特异性
- PTPN2 Antibody detects endogenous levels of total PTPN2.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PTPN2, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PTPN2 Primary Antibody
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anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) (AA 1-353) antibody
PTPN2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) (AA 1-257) antibodyPTPN2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) (AA 1-387) antibodyPTPN2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) antibodyPTPN2 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) antibodyPTPN2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) (AA 201-250) antibodyPTPN2 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 兔, 犬, Cow, 斑马鱼, 小鸡, 猴, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) (AA 1-330) antibodyPTPN2 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) (AA 329-358), (C-Term) antibodyPTPN2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB33304 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) antibodyPTPN2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) (AA 1-387) antibodyPTPN2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
- 别名
- PTPN2 (PTPN2 产品)
- 背景
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Description: Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA.
Gene: PTPN2
- 分子量
- 49kDa
- 基因ID
- 5771
- UniProt
- P17706
- 途径
- EGFR Signaling Pathway, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling
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