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PKD2 抗体 (C-Term)

Name: PKD2 抗体 (C-Term)
SKU: ABIN6264257
Availability: OutOfStock

This anti-PKD2 antibody is a 兔多克隆 antibody detecting PKD2 in WB 和 ELISA. Suitable for 人.

Western blot analysis of extracts of Human kidney tissue sample,using PKD2 Antibody(ABIN6272788). (PKD2 抗体 (C-Term))

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产品编号 ABIN6264257

发货至: 中国

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Quick Overview for PKD2 抗体 (C-Term) (ABIN6264257)

抗原

See all PKD2 抗体

PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

适用

人

宿主

兔

克隆类型

多克隆

标记

This PKD2 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA

Discover our top product PKD2 Primary Antibody

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C-Term

特异性

PKD2 Antibody detects endogenous levels of total PKD2.

预测反应

Zebrafish,Horse,Rabbit,Dog,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human PKD2, corresponding to a region within C-terminal amino acids.

亚型

IgG
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 261-360) antibody
PKD2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4C8 unconjugated

anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 621-832) antibody
PKD2 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 327-539) antibody
PKD2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 240-410) antibody
PKD2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 680-968) antibody
PKD2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (pSer876) antibody
PKD2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 261-360) antibody
PKD2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G3 unconjugated

anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 914-927), (Intracellular) antibody
PKD2 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated

anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) (AA 651-750) antibody
PKD2 适用: 人, 小鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) antibody
PKD2 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 25GB655 unconjugated

应用备注

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2))

别名

PKD2

背景

Description: Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (PubMed:18695040). Functions as outward-rectifying K+ channel, but is also permeable to Ca2+, and to a much lesser degree also to Na+ (PubMed:11854751, PubMed:15692563, PubMed:27071085, PubMed:27991905). May contribute to the release of Ca2+ stores from the endoplasmic reticulum (PubMed:11854751, PubMed:20881056). Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary to maintain the normal, differentiated state of renal tubule cells. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left-right axis specification via its role in sensing nodal flow, forms a complex with PKD1L1 in cilia to facilitate flow detection in left-right patterning. Detection of asymmetric nodal flow gives rise to a Ca2+ signal that is required for normal, asymmetric expression of genes involved in the specification of body left-right laterality (By similarity).
Gene: PKD2

分子量

96kDa

基因ID

5311

UniProt

Q13563

途径

cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity