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PDGFRA 抗体 (C-Term)

Name: PDGFRA 抗体 (C-Term)
SKU: ABIN6264101
Availability: OutOfStock

This anti-PDGFRA antibody is a 兔多克隆 antibody detecting PDGFRA in WB, ELISA, IHC, IF 和 ICC. Suitable for 人, 小鼠和大鼠.

Western blot analysis of PDGFR α expression in HepG2 cells. (PDGFRA 抗体 (C-Term))

IF/ICC

ABIN6269031 at 1/100 staining Human liver cancer tissue by IHC-P. (PDGFRA 抗体 (C-Term))

IHC

3 images

产品编号 ABIN6264101

发货至: 中国

Datasheet as PDF

Quick Overview for PDGFRA 抗体 (C-Term) (ABIN6264101)

抗原

See all PDGFRA 抗体

PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This PDGFRA antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Discover our top product PDGFRA Primary Antibody

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C-Term

特异性

PDGF Receptor alpha Antibody detects endogenous levels of total PDGF Receptor alpha.

预测反应

Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human PDGF Receptor alpha, corresponding to a region within C-terminal amino acids.

亚型

IgG
anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 179-361) antibody
PDGFRA 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 5B11G5 unconjugated

anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 361-528) antibody
PDGFRA 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 8E12F2 unconjugated

anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 331-719) antibody
PDGFRA 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 1-210) antibody
PDGFRA 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 179-361) antibody
PDGFRA 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1A10A8 unconjugated

anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 698-727) antibody
PDGFRA 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB11101 unconjugated

anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 1048-1077) antibody
PDGFRA 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 1021-1089) antibody
PDGFRA 适用: 人, 小鼠, 大鼠, 犬 ELISA, IHC (p), IF (p), IF (cc), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 1-1089) antibody
PDGFRA 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Platelet Derived Growth Factor Receptor alpha (PDGFRA) (AA 25-218) antibody
PDGFRA 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4H1-1C9 unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))

别名

PDGFRA

背景

Description: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades, the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
Gene: PDGFRA

分子量

140 kDa

基因ID

5156

UniProt

P16234

途径

RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling