NPC2 抗体 (N-Term)
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北京 101111
Quick Overview for NPC2 抗体 (N-Term) (ABIN6263698)
抗原
See all NPC2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- NPC2 Antibody detects endogenous levels of total NPC2.
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预测反应
- Horse,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human NPC2, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Niemann-Pick Disease, Type C2 (NPC2) antibody
NPC2 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C2 (NPC2) (AA 1-151) antibodyNPC2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C2 (NPC2) antibodyKD Validated NPC2 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB13695 unconjugated Recombinant Antibody
anti-Niemann-Pick Disease, Type C2 (NPC2) (AA 1-151) antibodyNPC2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C2 (NPC2) (AA 20-151) antibodyNPC2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C2 (NPC2) antibodyNPC2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C2 (NPC2) (AA 1-151) antibodyNPC2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4B9 unconjugated
anti-Niemann-Pick Disease, Type C2 (NPC2) (AA 52-151) antibodyNPC2 适用: 人 ELISA, IP 宿主: 小鼠 Monoclonal 1F4 unconjugated
anti-Niemann-Pick Disease, Type C2 (NPC2) (AA 1-151) antibodyNPC2 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C2 (NPC2) (AA 20-80) antibodyNPC2 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- NPC2 (Niemann-Pick Disease, Type C2 (NPC2))
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别名
- NPC2
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背景
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Description: Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
Gene: NPC2
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分子量
- 17kDa
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基因ID
- 10577
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UniProt
- P61916
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途径
- SARS-CoV-2 Protein Interactome
抗原
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