Nicastrin 抗体 (C-Term)
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Quick Overview for Nicastrin 抗体 (C-Term) (ABIN6263547)
抗原
See all Nicastrin (NCSTN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- NCSTN Antibody detects endogenous levels of total NCSTN.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human NCSTN, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Nicastrin (NCSTN) antibody
KD Validated NCSTN 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB1040 unconjugated Recombinant Antibody
anti-Nicastrin (NCSTN) (AA 429-669) antibodyNCSTN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 16-115) antibodyNCSTN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 21-120) antibodyNCSTN 适用: 小鼠 WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 99-133) antibodyNCSTN 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal RB53031 unconjugated
anti-Nicastrin (NCSTN) (AA 1-689) antibodyNCSTN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 16-115) antibodyNCSTN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E8 unconjugated
anti-Nicastrin (NCSTN) (AA 420-655) antibodyNCSTN 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (AA 35-534) antibodyNCSTN 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Nicastrin (NCSTN) (N-Term) antibodyNCSTN 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- Nicastrin (NCSTN)
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别名
- NCSTN
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背景
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Description: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
Gene: NCSTN
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分子量
- 77kDa
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基因ID
- 23385
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UniProt
- Q92542
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途径
- Notch Signaling, Neurotrophin Signaling Pathway
抗原
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