MYOC 抗体 (Internal Region)
Quick Overview for MYOC 抗体 (Internal Region) (ABIN6263485)
抗原
See all MYOC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- MYOC Antibody detects endogenous levels of total MYOC.
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预测反应
- Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human MYOC, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Myocilin (MYOC) (AA 36-135) antibody
MYOC 适用: 人 WB, ELISA, IP, IHC (p), RNAi 宿主: 小鼠 Monoclonal 4F8 unconjugated
anti-Myocilin (MYOC) (AA 224-471) antibodyMYOC 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myocilin (MYOC) (AA 183-294) antibodyMYOC 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myocilin (MYOC) (AA 1-504) antibodyMYOC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Myocilin (MYOC) (AA 1-504) antibodyMYOC 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B4 unconjugated
anti-Myocilin (MYOC) (AA 1-504) antibodyMYOC 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Myocilin (MYOC) (AA 245-504) antibodyMYOC 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Myocilin (MYOC) antibodyMYOC 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- MYOC (Myocilin (MYOC))
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别名
- MYOC
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背景
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Description: Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.
Gene: MYOC
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分子量
- 57kDa
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基因ID
- 4653
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UniProt
- Q99972
抗原
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