KDM5A 抗体 (C-Term)
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北京 101111
Quick Overview for KDM5A 抗体 (C-Term) (ABIN6262765)
抗原
See all KDM5A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- KDM5A Antibody detects endogenous levels of total KDM5A.
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预测反应
- Pig,Horse,Dog,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human KDM5A, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Lysine (K)-Specific Demethylase 5A (KDM5A) (AA 1416-1434) antibody
KDM5A 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 18E8 unconjugated
anti-Lysine (K)-Specific Demethylase 5A (KDM5A) antibodyKDM5A 适用: 人 WB, IP, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5A (KDM5A) (AA 191-290) antibodyKDM5A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1H2 unconjugated
anti-Lysine (K)-Specific Demethylase 5A (KDM5A) (AA 101-200) antibodyKDM5A 适用: 人 WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5A (KDM5A) (AA 437-603) antibodyKDM5A 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5A (KDM5A) (AA 191-290) antibodyKDM5A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5A (KDM5A) antibodyKDM5A 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 5A (KDM5A) (AA 1609-1641), (C-Term) antibodyKDM5A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB10761 unconjugated
anti-Lysine (K)-Specific Demethylase 5A (KDM5A) (AA 1608-1641), (C-Term) antibodyKDM5A 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- KDM5A (Lysine (K)-Specific Demethylase 5A (KDM5A))
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别名
- KDM5A
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背景
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Description: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed:27427228).
Gene: KDM5A
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分子量
- 192kDa
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基因ID
- 5927
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UniProt
- P29375
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途径
- Chromatin Binding, Warburg Effect
抗原
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