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IL28A 抗体 (N-Term)

The 兔 多克隆 anti-IL28A antibody is suitable to detect IL28A in samples from 人. It has been validated for WB, ICC, ELISA 和 IF.
产品编号 ABIN6262560
发货至: 中国
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Quick Overview for IL28A 抗体 (N-Term) (ABIN6262560)

抗原

See all IL28A 抗体
IL28A (Interleukin 28A (Interferon, lambda 2) (IL28A))

适用

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宿主

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克隆类型

  • 30
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多克隆

标记

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This IL28A antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunocytochemistry (ICC), ELISA, Immunofluorescence (IF)
  • 抗原表位

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    N-Term

    特异性

    IL28A Antibody detects endogenous levels of total IL28A.

    纯化方法

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    免疫原

    A synthesized peptide derived from human IL28A, corresponding to a region within N-terminal amino acids.

    亚型

    IgG
  • 应用备注

    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C. Stable for 12 months from date of receipt.

    有效期

    12 months
  • 抗原

    IL28A (Interleukin 28A (Interferon, lambda 2) (IL28A))

    别名

    IFNL2

    背景

    Description: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

    Gene: IFNL2

    分子量

    22 kDa

    基因ID

    282616

    UniProt

    Q8IZJ0
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