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HEXIM1 抗体

This anti-HEXIM1 antibody is a 兔 多克隆 antibody detecting HEXIM1 in WB, ELISA, IF 和 ICC. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6262224
发货至: 中国

Quick Overview for HEXIM1 抗体 (ABIN6262224)

抗原

See all HEXIM1 抗体
HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This HEXIM1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
  • 特异性

    HEXIM1 Antibody detects endogenous levels of HEXIM1

    交叉反应

    人, 小鼠, 大鼠

    纯化方法

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    免疫原

    A synthesized peptide derived from human HEXIM1

    亚型

    IgG
  • 应用备注

    WB 1:500-1:2000 IF/ICC 1:100-1:500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C.Stable for 12 months from date of receipt

    有效期

    12 months
  • 抗原

    HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))

    别名

    HEXIM1

    背景

    Description: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

    Gene: HEXIM1

    分子量

    40kDa

    基因ID

    10614

    UniProt

    O94992
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