HEXIM1 抗体
Quick Overview for HEXIM1 抗体 (ABIN6262224)
抗原
See all HEXIM1 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
 - HEXIM1 Antibody detects endogenous levels of HEXIM1
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交叉反应
 - 人, 小鼠, 大鼠
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纯化方法
 - The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
 - A synthesized peptide derived from human HEXIM1
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亚型
 - IgG
 
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应用备注
 - WB 1:500-1:2000 IF/ICC 1:100-1:500
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1 mg/mL
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缓冲液
 - Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
 - Sodium azide
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注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - -20 °C
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储存方法
 - Store at -20 °C.Stable for 12 months from date of receipt
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有效期
 - 12 months
 
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- HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))
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别名
 - HEXIM1
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背景
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Description: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Gene: HEXIM1
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分子量
 - 40kDa
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基因ID
 - 10614
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UniProt
 - O94992
 
抗原
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