Golgin A2 (GOLGA2) (N-Term) 抗体
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北京 101111
Quick Overview for Golgin A2 (GOLGA2) (N-Term) 抗体 (ABIN6262002)
抗原
See all Golgin A2 (GOLGA2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- GM130 Antibody detects endogenous levels of total GM130.
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预测反应
- Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human GM130, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Golgin A2 (GOLGA2) (AA 20-300) antibody
GOLGA2 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Golgin A2 (GOLGA2) (AA 1-990) antibodyGOLGA2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Golgin A2 (GOLGA2) antibodyKD Validated GOLGA2 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB5570 unconjugated Recombinant Antibody
anti-Golgin A2 (GOLGA2) (AA 1-345) antibodyGOLGA2 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Golgin A2 (GOLGA2) antibodyGOLGA2 适用: 人, 大鼠, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Golgin A2 (GOLGA2) (AA 1-990) antibodyGOLGA2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Golgin A2 (GOLGA2) (AA 1-120) antibodyGOLGA2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C6 unconjugated
anti-Golgin A2 (GOLGA2) (AA 20-300) antibodyGOLGA2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Golgin A2 (GOLGA2) (AA 851-1002) antibodyGOLGA2 适用: 人, 大鼠, 小鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Golgin A2 (GOLGA2) antibodyGOLGA2 适用: 人, 大鼠, 小鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:50-200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- Golgin A2 (GOLGA2)
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别名
- GOLGA2
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背景
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Description: Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis (By similarity). Also plays a key role in spindle pole assembly and centrosome organization (PubMed:26165940). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic spindle pole assembly, probably via the same mechanism (By similarity). Also regulates the centrosome organization (PubMed:18045989, PubMed:19109421). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (PubMed:16489344, PubMed:17314401).
Gene: GOLGA2
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分子量
- 130 kDa
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基因ID
- 2801
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UniProt
- Q08379
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途径
- SARS-CoV-2 Protein Interactome
抗原
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