GFI1B 抗体 (Internal Region)
Quick Overview for GFI1B 抗体 (Internal Region) (ABIN6261941)
抗原
See all GFI1B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- GFI1B Antibody detects endogenous levels of total GFI1B.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human GFI1B, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (N-Term) antibody
GFI1B 适用: 人, 小鼠, 大鼠, Cow, 犬, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (Internal Region) antibodyGFI1B 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (N-Term) antibodyGFI1B 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 山羊, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) antibodyGFI1B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (AA 2-110) antibodyGFI1B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (AA 1-330) antibodyGFI1B 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Growth Factor Independent 1B Transcription Repressor (GFI1B) (AA 302-330), (C-Term) antibodyGFI1B 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB44051 unconjugated
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应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- GFI1B (Growth Factor Independent 1B Transcription Repressor (GFI1B))
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别名
- GFI1B
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背景
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Description: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context, represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1, GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription, as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.
Gene: GFI1B
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分子量
- 37 kDa
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基因ID
- 8328
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UniProt
- Q5VTD9
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途径
- Cellular Response to Molecule of Bacterial Origin
抗原
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