FHIT 抗体 (Internal Region)
Quick Overview for FHIT 抗体 (Internal Region) (ABIN6261741)
抗原
See all FHIT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- FHIT Antibody detects endogenous levels of total FHIT.
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预测反应
- Rabbit,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human FHIT, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Fragile Histidine Triad (FHIT) (AA 25-147) antibody
FHIT 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Fragile Histidine Triad (FHIT) (AA 1-147) antibodyFHIT 适用: 人, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Fragile Histidine Triad (FHIT) antibodyFHIT 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fragile Histidine Triad (FHIT) (AA 31-130) antibodyFHIT 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 1H2 unconjugated
anti-Fragile Histidine Triad (FHIT) (AA 31-147) antibodyFHIT 适用: 人 ELISA, WB, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fragile Histidine Triad (FHIT) (AA 2-147) antibodyFHIT 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fragile Histidine Triad (FHIT) (AA 31-130) antibodyFHIT 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3D3 unconjugated
anti-Fragile Histidine Triad (FHIT) (AA 31-130) antibodyFHIT 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1C3 unconjugated
anti-Fragile Histidine Triad (FHIT) (AA 31-130) antibodyFHIT 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1C5 unconjugated
anti-Fragile Histidine Triad (FHIT) (AA 81-130) antibodyFHIT 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- FHIT (Fragile Histidine Triad (FHIT))
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别名
- FHIT
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背景
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Description: Cleaves P1-P3-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P1-P4-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P1-P3-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca2+ transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
Gene: FHIT
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分子量
- 16kDa
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基因ID
- 2272
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UniProt
- P49789
抗原
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