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Fibrillarin 抗体 (Internal Region)

This anti-Fibrillarin antibody is a 兔 多克隆 antibody detecting Fibrillarin in WB, IHC 和 ELISA. Suitable for 人, 大鼠 和 小鼠.
产品编号 ABIN6261689
发货至: 中国

Quick Overview for Fibrillarin 抗体 (Internal Region) (ABIN6261689)

抗原

See all Fibrillarin (FBL) 抗体
Fibrillarin (FBL)

适用

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人, 大鼠, 小鼠

宿主

  • 51
  • 10
  • 1

克隆类型

  • 47
  • 15
多克隆

标记

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This Fibrillarin antibody is un-conjugated

应用范围

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  • 2
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  • 1
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Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • 抗原表位

    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
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    Internal Region

    特异性

    FBL Antibody detects endogenous levels of total FBL.

    预测反应

    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog

    纯化方法

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    免疫原

    A synthesized peptide derived from human FBL, corresponding to a region within the internal amino acids.

    亚型

    IgG
  • 应用备注

    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C. Stable for 12 months from date of receipt.

    有效期

    12 months
  • 抗原

    Fibrillarin (FBL)

    别名

    FBL

    背景

    Description: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).

    Gene: FBL

    分子量

    34kDa

    基因ID

    2091

    UniProt

    P22087

    途径

    Ribonucleoside Biosynthetic Process
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