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Cyclin D2 抗体 (C-Term)

This anti-Cyclin D2 antibody is a Rabbit Polyclonal antibody detecting Cyclin D2 in WB, ELISA, IF, ICC. Suitable for Human, Mouse, Rat.
产品编号 ABIN6261147
发货至: 中国

Quick Overview for Cyclin D2 抗体 (C-Term) (ABIN6261147)

抗原

See all Cyclin D2 (CCND2) 抗体
Cyclin D2 (CCND2)

适用

人, 小鼠, 大鼠

宿主

  • 68
  • 23

克隆类型

  • 71
  • 20
多克隆

标记

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This Cyclin D2 antibody is un-conjugated

应用范围

  • 68
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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
  • 抗原表位

    • 16
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    C-Term

    特异性

    Cyclin D2 Antibody detects endogenous levels of total Cyclin D2.

    预测反应

    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

    纯化方法

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    免疫原

    A synthesized peptide derived from human Cyclin D2, corresponding to a region within C-terminal amino acids.

    亚型

    IgG
  • 应用备注

    WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C. Stable for 12 months from date of receipt.

    有效期

    12 months
  • 抗原

    Cyclin D2 (CCND2)

    别名

    CCND2

    背景

    Description: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

    Gene: CCND2

    分子量

    33 kDa

    基因ID

    894

    UniProt

    P30279

    途径

    Cell Division Cycle, Mitotic G1-G1/S Phases
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