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DDIT3 抗体 (N-Term)

Name: DDIT3 抗体 (N-Term)
SKU: ABIN6260816
Availability: OutOfStock

This anti-DDIT3 antibody is a 兔多克隆 antibody detecting DDIT3 in WB, IHC, ELISA, IF 和 ICC. Suitable for 人和小鼠. This Primary Antibody has been cited in 4+ publications.

Western blot analysis of CHOP expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (DDIT3 抗体 (N-Term))

IF/ICC

ABIN6269226 at 1/100 staining Human gastric tissue by IHC-P. (DDIT3 抗体 (N-Term))

IHC

IF/ICC

4 images

(4 references)

产品编号 ABIN6260816

发货至: 中国

Datasheet as PDF

Quick Overview for DDIT3 抗体 (N-Term) (ABIN6260816)

抗原

See all DDIT3 抗体

DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This DDIT3 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Discover our top product DDIT3 Primary Antibody

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N-Term

特异性

DDIT3 Antibody detects endogenous levels of total DDIT3.

预测反应

Pig,Bovine,Horse,Sheep,Rabbit,Dog

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human DDIT3, corresponding to a region within N-terminal amino acids.

亚型

IgG
anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (C-Term) antibody
DDIT3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-169) antibody
DDIT3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (N-Term) antibody
DDIT3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (pSer30) antibody
DDIT3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 120-149), (C-Term) antibody
DDIT3 适用: 人, 小鼠 WB, IF, FACS 宿主: 兔 Polyclonal RB13788 unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-169) antibody
DDIT3 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (Ser301) antibody
DDIT3 适用: 人, 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-90) antibody
DDIT3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G3 unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 75-168) antibody
DDIT3 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-DNA-Damage-Inducible Transcript 3 (DDIT3) (AA 1-90) antibody
DDIT3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
Yang, He, Li, Zhang, He, Duan, Huang, Xiang: "SWNHs (Single-Wall Carbon Nanohorns) Supervises Endoplasmic Reticulum (ER) Stress in Hepatocellular Carcinoma." in: Journal of nanoscience and nanotechnology, Vol. 18, Issue 10, pp. 6740-6745, (2018) (PubMed).

Feng, Li, Chen: "Tanshinone IIA ameliorates apoptosis of cardiomyocytes induced by endoplasmic reticulum stress." in: Experimental biology and medicine (Maywood, N.J.), Vol. 241, Issue 18, pp. 2042-2048, (2017) (PubMed).

Liu, Yu, Yang, Tian, Feng: "WITHDRAWN: Decreased level of endogenous ghrelin is involved in the progression of lung injury induced by oleic acid." in: Life sciences, (2017) (PubMed).

Yang, Teng, Li, Xue, Guo, Xiao, Wu: "Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress." in: Oxidative medicine and cellular longevity, Vol. 2016, pp. 9095242, (2016) (PubMed).
抗原

DDIT3 (DNA-Damage-Inducible Transcript 3 (DDIT3))

别名

DDIT3

背景

Description: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates, expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
Gene: DDIT3

分子量

19kDa

基因ID

1649

UniProt

P35638

途径

Regulation of Muscle Cell Differentiation, ER-Nucleus Signaling, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis