CD3D 抗体 (Internal Region)
Quick Overview for CD3D 抗体 (Internal Region) (ABIN6260618)
抗原
See all CD3D 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- CD3D Antibody detects endogenous levels of total CD3D.
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预测反应
- Bovine,Horse,Sheep
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CD3D, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 127-171) antibody
CD3D 适用: 人 ICC, ELISA, FACS 宿主: 小鼠 Monoclonal 6B6B12 unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 127-171) antibodyCD3D 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4B9G9 unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-105) antibodyCD3D 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 1F6A8 unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 18-113) antibodyCD3D 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 1-171) antibodyCD3D 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-105) antibodyCD3D 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 127-171) antibodyCD3D 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1H12G5 unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) antibodyCD3D 适用: 人, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-106) antibodyCD3D 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-CD3d Molecule, delta (CD3-TCR Complex) (CD3D) (AA 22-105) antibodyCD3D 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))
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别名
- CD3D
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背景
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Description: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456).
Gene: CD3D
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分子量
- 19kDa
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基因ID
- 915
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UniProt
- P04234
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途径
- TCR Signaling, CXCR4-mediated Signaling Events
抗原
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