CD163 抗体 (N-Term)
Quick Overview for CD163 抗体 (N-Term) (ABIN6260578)
抗原
See all CD163 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - N-Term
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特异性
 - CD163 Antibody detects endogenous levels of total CD163.
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预测反应
 - Pig,Bovine,Horse,Rabbit,Dog
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纯化方法
 - The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
 - A synthesized peptide derived from human CD163, corresponding to a region within N-terminal amino acids.
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亚型
 - IgG
 
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应用备注
 - WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1 mg/mL
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缓冲液
 - Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
 - Sodium azide
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注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
 - -20 °C
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储存方法
 - Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
 - 12 months
 
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- CD163
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别名
 - CD163
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背景
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Description: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
Gene: CD163
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分子量
 - 125 kDa
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基因ID
 - 9332
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UniProt
 - Q86VB7
 
抗原
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