ARID1A 抗体 (Internal Region)
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北京 101111
Quick Overview for ARID1A 抗体 (Internal Region) (ABIN6260038)
抗原
See all ARID1A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- ARI1A Antibody detects endogenous levels of total ARI1A.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human ARI1A, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-AT Rich Interactive Domain 1A (SWI-Like) (ARID1A) antibody
KD Validated ARID1A 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB3230 unconjugated Recombinant Antibody
anti-AT Rich Interactive Domain 1A (SWI-Like) (ARID1A) antibodyARID1A 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-AT Rich Interactive Domain 1A (SWI-Like) (ARID1A) (AA 655-816) antibodyARID1A 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-AT Rich Interactive Domain 1A (SWI-Like) (ARID1A) (AA 1930-1964) antibodyARID1A 适用: 人 WB 宿主: 兔 Polyclonal RB53541 unconjugated
anti-AT Rich Interactive Domain 1A (SWI-Like) (ARID1A) (AA 1717-1750) antibodyARID1A 适用: 人 WB 宿主: 兔 Polyclonal RB53540 unconjugated
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应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))
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别名
- ARID1A
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背景
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Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Gene: ARID1A
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分子量
- 242kDa
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基因ID
- 8289
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UniProt
- O14497
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Tube Formation
抗原
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