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ARF1 抗体 (Internal Region)

This anti-ARF1 antibody is a 兔 多克隆 antibody detecting ARF1 in WB, ELISA 和 IHC. Suitable for 人 和 小鼠.
产品编号 ABIN6260020
发货至: 中国

Quick Overview for ARF1 抗体 (Internal Region) (ABIN6260020)

抗原

See all ARF1 抗体
ARF1 (ADP-Ribosylation Factor 1 (ARF1))

适用

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人, 小鼠

宿主

  • 69
  • 43
  • 1

克隆类型

  • 59
  • 54
多克隆

标记

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This ARF1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 抗原表位

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    Internal Region

    特异性

    ARF1 Antibody detects endogenous levels of total ARF1.

    预测反应

    Pig,Zebrafish,Bovine,Sheep,Rabbit,Chicken,Xenopus

    纯化方法

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    免疫原

    A synthesized peptide derived from human ARF1, corresponding to a region within the internal amino acids.

    亚型

    IgG
  • 应用备注

    WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C. Stable for 12 months from date of receipt.

    有效期

    12 months
  • 抗原

    ARF1 (ADP-Ribosylation Factor 1 (ARF1))

    别名

    ARF1

    背景

    Description: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity, the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

    Gene: ARF1

    分子量

    20 kDa

    基因ID

    375

    UniProt

    P84077

    途径

    Transition Metal Ion Homeostasis, Inositol Metabolic Process
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