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APP 抗体 (C-Term)

Name: APP 抗体 (C-Term)
SKU: ABIN6259922
Availability: OutOfStock

Cited in 1 publication. This 兔多克隆 anti-APP antibody specifically detects APP in WB, ELISA, IHC, IF 和 ICC. The antibody is reactive with 人, 小鼠和大鼠 samples.

Western blot analysis of Amyloid beta A4 expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (APP 抗体 (C-Term))

ABIN6269089 at 1/100 staining Rat brain tissue by IHC-P. (APP 抗体 (C-Term))

IHC

ABIN6269089 staining HepG2? (APP 抗体 (C-Term))

IF/ICC

5 images

(1 reference)

产品编号 ABIN6259922

发货至: 中国

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Quick Overview for APP 抗体 (C-Term) (ABIN6259922)

抗原

See all APP 抗体

APP (Amyloid beta (A4) Precursor Protein (APP))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This APP antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Discover our top product APP Primary Antibody

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C-Term

特异性

APP Antibody detects endogenous levels of total APP.

预测反应

Pig,Horse,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human APP, corresponding to a region within C-terminal amino acids.

亚型

IgG
anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term) antibody
APP 适用: 人 WB, IF, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) antibody
APP 适用: 人, 小鼠 WB, ELISA, IHC, IF, FM 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 666-670) antibody
APP 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-270) antibody
APP 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 381-480) antibody
APP 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (pThr668) antibody
APP 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) antibody
KD Validated APP 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB1535 unconjugated Recombinant Antibody

anti-Amyloid beta (A4) Precursor Protein (APP) antibody
APP 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (C-Term) antibody
APP 适用: 人, 小鼠, 大鼠 WB, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-286) antibody
APP 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
Wen, You, Wang, Meng, Feng, Yang: "Polarization of Microglia to the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Manner Attenuates Axonal Injury Induced by Traumatic Brain Injury in Mice." in: Journal of neurotrauma, (2018) (PubMed).
抗原

APP (Amyloid beta (A4) Precursor Protein (APP))

别名

APP

背景

Description: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu2+ ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.
Gene: APP

分子量

117kDa

基因ID

351

UniProt

P05067

途径

Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour