AGRN 抗体 (C-Term)
Quick Overview for AGRN 抗体 (C-Term) (ABIN6259829)
抗原
See all AGRN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- AGRN Antibody detects endogenous levels of total AGRN.
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预测反应
- Pig,Zebrafish,Bovine,Dog,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human AGRN, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Agrin (AGRN) (AA 1206-1475) antibody
AGRN 适用: 大鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 1329-1548) antibodyAGRN 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 968-1130) antibodyAGRN 适用: 人 IHC, WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 30-350) antibodyAGRN 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 1856-2045) antibodyAGRN 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (AA 1130-1401) antibodyAGRN 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Agrin (AGRN) (N-Term) antibodyAGRN 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- AGRN (Agrin (AGRN))
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别名
- AGRN
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背景
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Description: Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha3-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.
Gene: AGRN
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分子量
- 217kDa
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基因ID
- 375790
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UniProt
- O00468
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途径
- Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
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