PLK2 抗体 (Internal Region)
Quick Overview for PLK2 抗体 (Internal Region) (ABIN6259281)
抗原
See all PLK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- PLK2 Antibody detects endogenous levels of total PLK2.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human PLK2, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Polo-Like Kinase 2 (PLK2) (C-Term) antibody
PLK2 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 322-671) antibodyPLK2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 666-685), (C-Term) antibodyPLK2 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 375-406), (C-Term) antibodyPLK2 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB0873 unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 585-685) antibodyPLK2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 1268-1341) antibodyPLK2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 336-685) antibodyPLK2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (Internal Region) antibodyPLK2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 261-310) antibodyPLK2 适用: 人, 小鼠, 大鼠, 豚鼠, 马, Cow, 犬, 兔, 斑马鱼, Bat, 小鸡, Hamster, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 2 (PLK2) (AA 354-382) antibodyPLK2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB34683 unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- PLK2 (Polo-Like Kinase 2 (PLK2))
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别名
- PLK2
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背景
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Description: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
Gene: PLK2
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分子量
- 78 kDa
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基因ID
- 10769
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UniProt
- Q9NYY3
抗原
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