RAD51C 抗体 (Internal Region)
Quick Overview for RAD51C 抗体 (Internal Region) (ABIN6259171)
抗原
See all RAD51C 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- Rad51C Antibody detects endogenous levels of total Rad51C.
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预测反应
- Sheep
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human Rad51C, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-DNA Repair Protein RAD51 Homolog 3 (RAD51C) (AA 1-134) antibody
RAD51C 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 3F3-5C6 unconjugated
anti-DNA Repair Protein RAD51 Homolog 3 (RAD51C) (Center) antibodyRAD51C 适用: 人, 猴 WB, IF, IHC, IC 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein RAD51 Homolog 3 (RAD51C) (Internal Region) antibodyRAD51C 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein RAD51 Homolog 3 (RAD51C) antibodyRAD51C 适用: 人 IF 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein RAD51 Homolog 3 (RAD51C) (AA 1-376) antibodyRAD51C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein RAD51 Homolog 3 (RAD51C) (AA 1-376) antibodyRAD51C 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-DNA Repair Protein RAD51 Homolog 3 (RAD51C) (N-Term) antibodyVerified RAD51C 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-DNA Repair Protein RAD51 Homolog 3 (RAD51C) (Internal Region) antibodyRAD51C 适用: 人, 猴 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein RAD51 Homolog 3 (RAD51C) (AA 1-135) antibodyRAD51C 适用: 人 IF 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein RAD51 Homolog 3 (RAD51C) (AA 1-135) antibodyRAD51C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- RAD51C (DNA Repair Protein RAD51 Homolog 3 (RAD51C))
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别名
- RAD51C
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背景
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Description: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment, CX3 seems to act downstream of RAD51 recruitment, both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process, the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.
Gene: RAD51C
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分子量
- 50 kDa
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基因ID
- 5889
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UniProt
- O43502
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途径
- DNA Damage Repair
抗原
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