FZD6 抗体 (C-Term)
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北京 101111
Quick Overview for FZD6 抗体 (C-Term) (ABIN6258792)
抗原
See all FZD6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- FZD6 Antibody detects endogenous levels of total FZD6.
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预测反应
- Rabbit
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human FZD6, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Frizzled Family Receptor 6 (FZD6) (N-Term) antibody
FZD6 适用: 人, 猴 IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 6 (FZD6) (AA 11-110) antibodyFZD6 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 6 (FZD6) antibodyFZD6 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 6 (FZD6) (AA 19-201) antibodyFZD6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 6 (FZD6) (AA 539-588) antibodyFZD6 适用: 人, 大鼠, 猴, Cow, 犬, 豚鼠, 马, Pig, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 6 (FZD6) (AA 116-165) antibodyFZD6 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Frizzled Family Receptor 6 (FZD6) (Extracellular Domain), (N-Term) antibodyFZD6 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- FZD6 (Frizzled Family Receptor 6 (FZD6))
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别名
- FZD6
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背景
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Description: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).
Gene: FZD6
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分子量
- 79 kDa
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基因ID
- 8323
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UniProt
- O60353
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途径
- WNT signaling, Tube Formation
抗原
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