FZD10 抗体
Quick Overview for FZD10 抗体 (ABIN6258746)
抗原
See all FZD10 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- FZD10 antibody detects endogenous levels of total FZD10
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交叉反应
- 人, 猴, 小鼠
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide
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亚型
- IgG
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应用备注
- WB 1:500-1:2000, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- FZD10 (Frizzled Family Receptor 10 (FZD10))
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别名
- FZD10
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背景
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Description: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
Gene: FZD10
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分子量
- 65 kDa
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基因ID
- 11211
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UniProt
- Q9ULW2
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途径
- WNT signaling
抗原
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