PMS2 抗体 (C-Term)
Quick Overview for PMS2 抗体 (C-Term) (ABIN6258635)
抗原
See all PMS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- PMS2 Antibody detects endogenous levels of total PMS2.
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预测反应
- Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human PMS2, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 748-851) antibody
PMS2 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 1E9D11 unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) antibodyPMS2 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6G12E1 unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 748-851) antibodyPMS2 适用: 人 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 8E4G11 unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 748-851) antibodyPMS2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 6A12H9 unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 1-862) antibodyPMS2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 763-862) antibodyPMS2 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 4D11 unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 390-670) antibodyPMS2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 1-862) antibodyPMS2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 763-862) antibodyPMS2 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 4A8 unconjugated
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (Internal Region) antibodyPMS2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2))
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别名
- PMS2
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背景
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Description: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages.
Gene: PMS2
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分子量
- 85 kDa
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基因ID
- 5395
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UniProt
- P54278
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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