ALKBH3 抗体 (Internal Region)
Quick Overview for ALKBH3 抗体 (Internal Region) (ABIN6258598)
抗原
See all ALKBH3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- ALKBH3 Antibody detects endogenous levels of total ALKBH3.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human ALKBH3, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-AlkB, Alkylation Repair Homolog 3 (ALKBH3) (AA 1-170) antibody
ALKBH3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 3 (ALKBH3) (AA 1-139) antibodyALKBH3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A5-4F5 unconjugated
anti-AlkB, Alkylation Repair Homolog 3 (ALKBH3) (AA 216-265) antibodyALKBH3 适用: 人, 小鼠, 大鼠, 马, 兔, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 3 (ALKBH3) (AA 1-286) antibodyALKBH3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 3 (ALKBH3) (AA 1-286) antibodyALKBH3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 3 (ALKBH3) (AA 242-269), (C-Term) antibodyALKBH3 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB22074 unconjugated
anti-AlkB, Alkylation Repair Homolog 3 (ALKBH3) (Middle Region) antibodyALKBH3 适用: 人, 小鼠, 大鼠, 马, 兔, Cow, 犬, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-AlkB, Alkylation Repair Homolog 3 (ALKBH3) (AA 1-286) antibody (APC)ALKBH3 适用: 人 IHC, IF, FACS, ICC 宿主: 兔 Polyclonal APC
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- ALKBH3 (AlkB, Alkylation Repair Homolog 3 (ALKBH3))
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别名
- ALKBH3
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背景
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Description: Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:25944111). Has a strong preference for single-stranded DNA (PubMed:12486230, PubMed:12594517, PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3 (PubMed:22055184). Also acts on RNA (PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410, PubMed:16858410). Demethylates N1-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons (PubMed:26863196, PubMed:26863410). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:22055184, PubMed:16858410).
Gene: ALKBH3
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分子量
- 33 kDa
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基因ID
- 221120
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UniProt
- Q96Q83
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途径
- DNA Damage Repair
抗原
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