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ATG16L1 抗体 (C-Term)

This anti-ATG16L1 antibody is a 兔 多克隆 antibody detecting ATG16L1 in WB, ELISA, IF 和 ICC. Suitable for 人 和 小鼠.
产品编号 ABIN6258588
发货至: 中国

Quick Overview for ATG16L1 抗体 (C-Term) (ABIN6258588)

抗原

See all ATG16L1 抗体
ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

适用

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人, 小鼠

宿主

  • 71
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  • 1

克隆类型

  • 63
  • 22
多克隆

标记

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This ATG16L1 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
  • 抗原表位

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    C-Term

    特异性

    ATG16L1 Antibody detects endogenous levels of total ATG16L1.

    预测反应

    Pig,Bovine,Horse,Sheep,Rabbit,Dog

    纯化方法

    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).

    免疫原

    A synthesized peptide derived from human ATG16L1, corresponding to a region within C-terminal amino acids.

    亚型

    IgG
  • 应用备注

    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C. Stable for 12 months from date of receipt.

    有效期

    12 months
  • 抗原

    ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

    别名

    ATG16L1

    背景

    Description: Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).

    Gene: ATG16L1

    分子量

    69 kDa

    基因ID

    55054

    UniProt

    Q676U5

    途径

    Autophagy
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