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Mesothelin 抗体 (C-Term)

Name: Mesothelin 抗体 (C-Term)
SKU: ABIN6258462
Availability: OutOfStock

This anti-Mesothelin antibody is a 兔多克隆 antibody detecting Mesothelin in ELISA, WB, IF 和 ICC. Suitable for 人, 小鼠和大鼠.

Western blot analysis of GPR30 expression in ; HepG2 cell lysate,The lane on the left is treated with the antigen-specific peptide. (Mesothelin 抗体 (C-Term))

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产品编号 ABIN6258462

发货至: 中国

Quick Overview for Mesothelin 抗体 (C-Term) (ABIN6258462)

抗原

See all Mesothelin (MSLN) 抗体

Mesothelin (MSLN)

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This Mesothelin antibody is un-conjugated

应用范围

ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

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C-Term

特异性

GPR30 Antibody detects endogenous levels of total GPR30.

预测反应

Pig,Horse,Dog,Chicken

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human GPR30, corresponding to a region within C-terminal amino acids.

亚型

IgG
anti-Mesothelin (MSLN) (AA 273-407) antibody
MSLN 适用: 人 IHC (f) 宿主: 小鼠 Monoclonal MSLN-2131 unconjugated

anti-Mesothelin (MSLN) (AA 101-200) antibody
MSLN 适用: 人 ELISA, WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Mesothelin (MSLN) (AA 273-407) antibody
MSLN 适用: 人 IHC (f) 宿主: 小鼠 Monoclonal unconjugated

anti-Mesothelin (MSLN) (AA 37-286) antibody
MSLN 适用: 人, 猴 ELISA, WB, FACS 宿主: 小鼠 Monoclonal 5C11A4 unconjugated

anti-Mesothelin (MSLN) (AA 37-598) antibody
MSLN 适用: 人 ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-Mesothelin (MSLN) (AA 296-580) antibody
MSLN 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal DM71 unconjugated Recombinant Antibody

anti-Mesothelin (MSLN) (AA 296-606) antibody
MSLN 适用: 人, 大鼠 ELISA, WB 宿主: 小鼠 Monoclonal 7E6A6 unconjugated

anti-Mesothelin (MSLN) (AA 37-286) antibody
MSLN 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4H12F8 unconjugated

anti-Mesothelin (MSLN) (AA 1-62) antibody
MSLN 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Mesothelin (MSLN) antibody
MSLN 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

有效期

12 months
抗原

Mesothelin (MSLN)

别名

GPER1

背景

Description: G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.
Gene: GPER1

分子量

42 kDa

基因ID

2852

UniProt

Q99527

途径

EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process