CELF1 抗体 (N-Term)
Quick Overview for CELF1 抗体 (N-Term) (ABIN6258447)
抗原
See all CELF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- CELF-1 Antibody detects endogenous levels of total CELF-1.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CELF-1, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-CUGBP, Elav-Like Family Member 1 (CELF1) (AA 108-483) antibody
CELF1 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-CUGBP, Elav-Like Family Member 1 (CELF1) (AA 1-483) antibodyCELF1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-CUGBP, Elav-Like Family Member 1 (CELF1) (AA 1-483) antibodyCELF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CUGBP, Elav-Like Family Member 1 (CELF1) antibodyCELF1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-CUGBP, Elav-Like Family Member 1 (CELF1) (Center) antibodyCELF1 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 小鸡 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-CUGBP, Elav-Like Family Member 1 (CELF1) (Internal Region) antibodyCELF1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CUGBP, Elav-Like Family Member 1 (CELF1) antibodyCELF1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-CUGBP, Elav-Like Family Member 1 (CELF1) (Internal Region) antibodyCELF1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CUGBP, Elav-Like Family Member 1 (CELF1) (AA 1-30), (N-Term) antibodyCELF1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB34074 unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CELF1 (CUGBP, Elav-Like Family Member 1 (CELF1))
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别名
- CELF1
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背景
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Description: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233).
Gene: CELF1
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分子量
- 52 kDa
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基因ID
- 10658
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UniProt
- Q92879
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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