CXCR7 抗体 (Internal Region)
Quick Overview for CXCR7 抗体 (Internal Region) (ABIN6258040)
抗原
See all CXCR7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- CXCR7 Antibody detects endogenous levels of total CXCR7.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CXCR7, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Chemokine (C-X-C Motif) Receptor 7 (CXCR7) antibody
KO Validated CXCR7 适用: 人 WB, ELISA, FACS, IF, IHC (p), IP, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 7 (CXCR7) antibodyCXCR7 适用: 人, 大鼠, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 7 (CXCR7) (AA 151-250) antibodyCXCR7 适用: 人, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 7 (CXCR7) (AA 311-360) antibodyCXCR7 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 7 (CXCR7) (Extracellular Domain) antibodyCXCR7 适用: 人, 大鼠, 小鼠, 犬, Cow, Pig, 马, Bat, Hamster, 兔 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 7 (CXCR7) (Cytoplasmic Domain) antibodyCXCR7 适用: 人, 马 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 7 (CXCR7) antibodyCXCR7 适用: 人 FACS 宿主: 小鼠 Monoclonal 10D1-J16 unconjugated
anti-Chemokine (C-X-C Motif) Receptor 7 (CXCR7) (AA 50-150) antibodyCXCR7 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-X-C Motif) Receptor 7 (CXCR7) (AA 330-358), (C-Term) antibodyCXCR7 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB23520 unconjugated
anti-Chemokine (C-X-C Motif) Receptor 7 (CXCR7) (AA 330-358) antibodyCXCR7 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CXCR7 (Chemokine (C-X-C Motif) Receptor 7 (CXCR7))
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别名
- ACKR3
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背景
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Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
Gene: ACKR3
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分子量
- 41 kDa
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基因ID
- 57007
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UniProt
- P25106
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途径
- Myometrial Relaxation and Contraction, Negative Regulation of intrinsic apoptotic Signaling
抗原
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