BOK 抗体 (N-Term)
Quick Overview for BOK 抗体 (N-Term) (ABIN6257961)
抗原
See all BOK 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- N-Term
-
特异性
- BOK Antibody detects endogenous levels of total BOK.
-
预测反应
- Pig,Bovine,Chicken,Xenopus
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human BOK, corresponding to a region within N-terminal amino acids.
-
亚型
- IgG
-
-
anti-BCL2-Related Ovarian Killer (BOK) (AA 1-100) antibody
BOK 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Related Ovarian Killer (BOK) (C-Term) antibodyBOK 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Related Ovarian Killer (BOK) antibodyBOK 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Related Ovarian Killer (BOK) (AA 60-90) antibodyBOK 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Related Ovarian Killer (BOK) (AA 15-103) antibodyBOK 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Related Ovarian Killer (BOK) (Internal Region) antibodyVerified BOK 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
-
-
应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
-
有效期
- 12 months
-
-
- BOK (BCL2-Related Ovarian Killer (BOK))
-
别名
- BOK
-
背景
-
Description: Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155).
Gene: BOK
-
分子量
- 23 kDa
-
基因ID
- 666
-
UniProt
- Q9UMX3
-
途径
- Positive Regulation of Endopeptidase Activity
抗原
-
