ACER2 抗体
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北京 101111
Quick Overview for ACER2 抗体 (ABIN6257827)
抗原
See all ACER2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- ASAH3L Antibody detects endogenous levels of total ASAH3L
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交叉反应
- 人, 小鼠
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide
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亚型
- IgG
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anti-Alkaline Ceramidase 2 (ACER2) (Internal Region) antibody
ACER2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 2 (ACER2) antibodyACER2 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 2 (ACER2) (Center) antibodyACER2 适用: 人, 小鼠, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 2 (ACER2) (Middle Region) antibodyACER2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 犬, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500~1:1000, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- ACER2 (Alkaline Ceramidase 2 (ACER2))
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别名
- ASAH3L
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背景
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Description: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.
Gene: ACER2
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分子量
- 33 kDa
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基因ID
- 340485
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UniProt
- Q5QJU3
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途径
- Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
抗原
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