ACER2 抗体
Quick Overview for ACER2 抗体 (ABIN6257827)
抗原
See all ACER2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
特异性
- ASAH3L Antibody detects endogenous levels of total ASAH3L
-
交叉反应
- 人, 小鼠
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide
-
亚型
- IgG
-
-
anti-Alkaline Ceramidase 2 (ACER2) (Internal Region) antibody
ACER2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 2 (ACER2) antibodyACER2 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 2 (ACER2) antibodyACER2 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 2 (ACER2) (Center) antibodyACER2 适用: 人, 小鼠, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Alkaline Ceramidase 2 (ACER2) (Middle Region) antibodyACER2 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 犬, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:500~1:1000, IF/ICC 1:100-1:500
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
-
有效期
- 12 months
-
-
- ACER2 (Alkaline Ceramidase 2 (ACER2))
-
别名
- ASAH3L
-
背景
-
Description: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.
Gene: ACER2
-
分子量
- 33 kDa
-
基因ID
- 340485
-
UniProt
- Q5QJU3
-
途径
- Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
抗原
-
