BST2 抗体 (Internal Region)
Quick Overview for BST2 抗体 (Internal Region) (ABIN6257788)
抗原
See all BST2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- BST2 Antibody detects endogenous levels of total BST2.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human BST2, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 1-180) antibody
BST2 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 2E6 unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 1-180) antibodyBST2 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 1-180) antibodyBST2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 40-180) antibodyBST2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H4 unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 49-161) antibodyBST2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 40-180) antibodyBST2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 40-180) antibodyBST2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 1-20) antibodyBST2 适用: 人, 小鼠 WB, FACS, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) (AA 49-161) antibodyBST2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bone Marrow Stromal Cell Antigen 2 (BST2) antibodyBST2 适用: 人, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))
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别名
- BST2
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背景
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Description: IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439). Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2 (PubMed:23028328).
Gene: BST2
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分子量
- 22 kDa
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基因ID
- 684
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UniProt
- Q10589
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途径
- Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response
抗原
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