CDK8 抗体 (N-Term)
Quick Overview for CDK8 抗体 (N-Term) (ABIN6257696)
抗原
See all CDK8 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- CDK8 Antibody detects endogenous levels of total CDK8.
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预测反应
- Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CDK8, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Cyclin-Dependent Kinase 8 (CDK8) (AA 375-464) antibody
CDK8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6H5 unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (AA 365-464) antibodyCDK8 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (C-Term) antibodyCDK8 适用: 人, 小鼠 WB, ChIP-seq, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (N-Term) antibodyCDK8 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (AA 21-392) antibodyCDK8 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (AA 424-458), (C-Term) antibodyCDK8 适用: 人 WB 宿主: 兔 Polyclonal RB51053 unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (N-Term) antibodyCDK8 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (C-Term) antibodyCDK8 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, 马, 兔, Cow, 小鸡, 非洲爪蟾, Pig, 猴, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 8 (CDK8) (N-Term) antibodyCDK8 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, 马, 兔, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CDK8 (Cyclin-Dependent Kinase 8 (CDK8))
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别名
- CDK8
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背景
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Description: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.
Gene: CDK8
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分子量
- 53 kDa
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基因ID
- 1024
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UniProt
- P49336
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途径
- Cell Division Cycle, Regulation of Lipid Metabolism by PPARalpha
抗原
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