E2F8 抗体 (C-Term)
Quick Overview for E2F8 抗体 (C-Term) (ABIN6257152)
抗原
See all E2F8 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- C-Term
-
特异性
- E2F8 Antibody detects endogenous levels of total E2F8.
-
预测反应
- Pig,Bovine,Horse,Dog
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human E2F8, corresponding to a region within C-terminal amino acids.
-
亚型
- IgG
-
-
anti-E2F Transcription Factor 8 (E2F8) (C-Term) antibody
E2F8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) (Internal Region) antibodyVerified E2F8 适用: 人 ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) antibodyE2F8 适用: 人, 大鼠, 小鼠, Pig, 小鸡 FACS 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) (AA 1-431) antibodyE2F8 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E9-2F5 unconjugated
anti-E2F Transcription Factor 8 (E2F8) (AA 1-240) antibodyE2F8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-E2F Transcription Factor 8 (E2F8) (AA 835-865) antibodyE2F8 适用: 人 WB 宿主: 兔 Polyclonal RB54144 unconjugated
anti-E2F Transcription Factor 8 (E2F8) (C-Term) antibodyE2F8 适用: 人, 大鼠, Pig, 犬, 豚鼠, 马, 猴, Bat, Hamster WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
有效期
- 12 months
-
-
- E2F8 (E2F Transcription Factor 8 (E2F8))
-
别名
- E2F8
-
背景
-
Description: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.
Gene: E2F8
-
分子量
- 94 kDa
-
基因ID
- 79733
-
UniProt
- A0AVK6
抗原
-
