AKAP13 抗体 (Internal Region)
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- 抗原 See all AKAP13 抗体
- AKAP13 (A Kinase (PRKA) Anchor Protein 13 (AKAP13))
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抗原表位
- Internal Region
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This AKAP13 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- AKAP13 Antibody detects endogenous levels of total AKAP13.
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human AKAP13, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product AKAP13 Primary Antibody
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anti-A Kinase (PRKA) Anchor Protein 13 (AKAP13) (AA 1-110) antibody
AKAP13 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D6 unconjugated
anti-A Kinase (PRKA) Anchor Protein 13 (AKAP13) (AA 1-110) antibodyAKAP13 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 5B7 unconjugated
anti-A Kinase (PRKA) Anchor Protein 13 (AKAP13) (AA 1-150) antibodyAKAP13 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 13 (AKAP13) (Center) antibodyAKAP13 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 13 (AKAP13) antibodyAKAP13 适用: 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 13 (AKAP13) (AA 18-170) antibodyAKAP13 适用: 人 WB 宿主: 小鼠 Monoclonal 1742CT411-87-24 unconjugated
anti-A Kinase (PRKA) Anchor Protein 13 (AKAP13) (AA 1-1058) antibodyAKAP13 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 13 (AKAP13) (AA 1-1058) antibodyAKAP13 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 13 (AKAP13) (AA 721-770) antibodyAKAP13 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- AKAP13 (A Kinase (PRKA) Anchor Protein 13 (AKAP13))
- 别名
- AKAP13 (AKAP13 产品)
- 别名
- AKAP13 antibody, brx antibody, lbc antibody, ha-3 antibody, ht31 antibody, c-lbc antibody, MGC81410 antibody, akap-lbc antibody, arhgef13 antibody, proto-lb antibody, proto-lbc antibody, AKAP-13 antibody, AKAP-Lbc antibody, ARHGEF13 antibody, BRX antibody, HA-3 antibody, Ht31 antibody, LBC antibody, PRKA13 antibody, PROTO-LB antibody, PROTO-LBC antibody, p47 antibody, 1700026G02Rik antibody, 5730522G15Rik antibody, 5830460E08Rik antibody, A-kinase anchoring protein 13 antibody, A-kinase anchoring protein 13 S homeolog antibody, A kinase (PRKA) anchor protein 13 antibody, AKAP13 antibody, akap13.S antibody, akap13 antibody, Akap13 antibody
- 背景
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Description: Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity).
Gene: AKAP13
- 分子量
- 307 kDa
- 基因ID
- 11214
- UniProt
- Q12802
- 途径
- Neurotrophin Signaling Pathway
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