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JAK2 抗体 (pTyr570)

Name: JAK2 抗体 (pTyr570)
SKU: ABIN6256765
Availability: OutOfStock

This anti-JAK2 antibody is a 兔多克隆 antibody detecting JAK2 in WB, ELISA, IF 和 ICC. Suitable for 人, 大鼠和小鼠.

Western blot analysis of JAK2 phosphorylation expression in etoposide treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (JAK2 抗体 (pTyr570))

IF/ICC

2 images

产品编号 ABIN6256765

发货至: 中国

Quick Overview for JAK2 抗体 (pTyr570) (ABIN6256765)

抗原

See all JAK2 抗体

JAK2 (Janus Kinase 2 (JAK2))

适用

人, 大鼠, 小鼠

宿主

兔

克隆类型

多克隆

标记

This JAK2 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Discover our top product JAK2 Primary Antibody

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pTyr570

特异性

Phospho-JAK2 (Tyr570) Antibody detects endogenous levels of JAK2 only when phosphorylated at Tyrosine 570.

预测反应

Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human JAK2 around the phosphorylation site of Tyr570.

亚型

IgG
anti-Janus Kinase 2 (JAK2) (pTyr1007), (pTyr1008) antibody
JAK2 适用: 人, 大鼠, 小鼠, 兔, 斑马鱼 WB, ELISA, FACS, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 2 (JAK2) (AA 508-800) antibody
JAK2 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 2 (JAK2) (AA 916-1103) antibody
JAK2 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 2 (JAK2) (AA 745-955) antibody
JAK2 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5C12C9 unconjugated

anti-Janus Kinase 2 (JAK2) (pTyr221) antibody
JAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 2 (JAK2) (pTyr931) antibody
JAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 2 (JAK2) (pTyr1007), (pTyr1008) antibody
JAK2 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Monoclonal 1A4 unconjugated Recombinant Antibody

anti-Janus Kinase 2 (JAK2) (C-Term) antibody
JAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 2 (JAK2) (AA 1101-1132) antibody
JAK2 适用: 人, 小鼠 WB, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 2 (JAK2) (N-Term) antibody
JAK2 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

JAK2 (Janus Kinase 2 (JAK2))

别名

JAK2

背景

Description: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO), or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980).
Gene: JAK2

分子量

125kDa

基因ID

3717

UniProt

O60674

途径

JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response