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Cortactin 抗体 (pTyr421)

This anti-Cortactin antibody is a 兔 多克隆 antibody detecting Cortactin in WB, ELISA, IF 和 ICC. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6256738
发货至: 中国

Quick Overview for Cortactin 抗体 (pTyr421) (ABIN6256738)

抗原

See all Cortactin (CTTN) 抗体
Cortactin (CTTN)

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This Cortactin antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
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    pTyr421

    特异性

    Phospho-Cortactin (Tyr421) Antibody detects endogenous levels of Cortactin only when phosphorylated at Tyrosine 421.

    预测反应

    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

    纯化方法

    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

    免疫原

    A synthesized peptide derived from human Cortactin around the phosphorylation site of Tyr421.

    亚型

    IgG
  • 应用备注

    WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20 °C. Stable for 12 months from date of receipt.

    有效期

    12 months
  • 抗原

    Cortactin (CTTN)

    别名

    CTTN

    背景

    Description: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).

    Gene: CTTN

    分子量

    85kDa

    基因ID

    2017

    UniProt

    Q14247

    途径

    MAPK Pathway
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