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CEBPB 抗体 (pThr235)

CEBPB 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6256518
发货至: 中国
  • 抗原 See all CEBPB 抗体
    CEBPB (CCAAT/enhancer Binding Protein (C/EBP), beta (CEBPB))
    抗原表位
    • 11
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    pThr235
    适用
    • 81
    • 40
    • 38
    • 8
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 70
    • 14
    • 1
    • 1
    克隆类型
    • 64
    • 22
    多克隆
    标记
    • 58
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    This CEBPB antibody is un-conjugated
    应用范围
    • 57
    • 31
    • 22
    • 14
    • 13
    • 13
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Phospho-CEBP Beta (Thr235/Thr188) Antibody detects endogenous levels of CEBP Beta only when phosphorylated at Threonine 235.
    预测反应
    Pig,Bovine,Rabbit,Dog
    纯化方法
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    免疫原
    A synthesized peptide derived from human C/EBP- beta around the phosphorylation site of Thr235.
    亚型
    IgG
    Top Product
    Discover our top product CEBPB Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    CEBPB (CCAAT/enhancer Binding Protein (C/EBP), beta (CEBPB))
    别名
    CEBPB (CEBPB 产品)
    别名
    C/EBPbeta antibody, c/ebp-beta antibody, crp2 antibody, il6dbp antibody, lap antibody, nf-il6 antibody, tcf5 antibody, xC/EBPbeta antibody, cebpbb antibody, cb380 antibody, c/ebpb antibody, fe11e05 antibody, wu:fe11e05 antibody, CEBPB antibody, LOC100136165 antibody, C/EBP-beta antibody, CRP2 antibody, IL6DBP antibody, LAP antibody, NF-IL6 antibody, TCF5 antibody, IL-6DBP antibody, LIP antibody, NF-M antibody, Nfil6 antibody, Il6dbp antibody, CCAAT/enhancer binding protein beta antibody, CCAAT/enhancer binding protein beta L homeolog antibody, CCAAT/enhancer binding protein (C/EBP), beta antibody, CCAAT/enhancer-binding protein beta antibody, cebpb antibody, cebpb.L antibody, CEBPB antibody, LOC100136165 antibody, Cebpb antibody
    背景

    Description: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1, represses expression of DSPP during odontoblast differentiation (By similarity).

    Gene: CEBPB

    分子量
    36kDa
    基因ID
    1051
    UniProt
    P17676
    途径
    Interferon-gamma Pathway, Autophagy, Brown Fat Cell Differentiation
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