beta Catenin 抗体 (pTyr489)
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北京 101111
Quick Overview for beta Catenin 抗体 (pTyr489) (ABIN6255928)
抗原
See all beta Catenin (CATNB) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr489
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原理
- Phospho-beta Catenin (Tyr489) Antibody
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特异性
- Phospho-beta Catenin (Tyr489) Antibody detects endogenous levels of beta Catenin only when phosphorylated at Tyrosine 489.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
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免疫原
- A synthesized peptide derived from human Catenin- beta around the phosphorylation site of Tyr489.
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亚型
- IgG
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anti-Catenin, beta (CATNB) (AA 661-781) antibody
CATNB 适用: 人 WB, FACS, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Catenin, beta (CATNB) (pSer33), (pSer37) antibodyCATNB 适用: 人 WB, FACS, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Catenin, beta (CATNB) (C-Term) antibodyCATNB 适用: 人, 小鼠, 大鼠, Cow, 小鸡, 犬, Pig, 兔, 绵羊, 猴, Hamster, Avian, Cat, 驴, 山羊, 豚鼠, 马 WB, IF, IHC (p), IHC (fro) 宿主: 山羊 Polyclonal unconjugated
anti-Catenin, beta (CATNB) (C-Term) antibodyCATNB 适用: 人, 斑马鱼 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 725-775) antibodyCATNB 适用: 人, 小鼠 WB, IHC, FACS, ICC, IP, IF (p) 宿主: 兔 Monoclonal BLR086G unconjugated Recombinant Antibody
anti-Catenin, beta (CATNB) antibodyCATNB 适用: 人, 小鼠, 大鼠, 斑马鱼 WB, IHC, IF 宿主: 小鼠 Monoclonal unconjugated
anti-Catenin, beta (CATNB) antibodyCATNB 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 小鼠 Monoclonal 4A3H3 unconjugated
anti-Catenin, beta (CATNB) (AA 439-675) antibodyCATNB 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Catenin, beta (CATNB) (AA 439-675) antibodyCATNB 适用: 人 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal C11 unconjugated
anti-Catenin, beta (CATNB) (AA 760-781) antibodyCATNB 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- beta Catenin (CATNB) (Catenin, beta (CATNB))
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别名
- beta Catenin
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背景
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Description: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
Gene: CTNNB1
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分子量
- 92kDa
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基因ID
- 1499
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UniProt
- P35222
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途径
- Peptide Hormone Metabolism
抗原
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