RPA2 抗体 (pThr21)
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- 抗原 See all RPA2 抗体
- RPA2 (Replication Protein A2, 32kDa (RPA2))
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抗原表位
- pThr21
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RPA2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Phospho-RPA32/RPA2 (Thr21) Antibody detects endogenous levels of RPA32/RPA2 only when phosphorylated at Threonine 21.
- 预测反应
- Pig,Zebrafish,Bovine,Sheep,Dog,Xenopus
- 纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- 免疫原
- A synthesized peptide derived from human RPA32/RPA2 around the phosphorylation site of Thr21.
- 亚型
- IgG
- Top Product
- Discover our top product RPA2 Primary Antibody
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anti-Replication Protein A2, 32kDa (RPA2) (AA 1-270) antibody
RPA2 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Replication Protein A2, 32kDa (RPA2) antibodyRPA2 适用: 人, 猴 WB, IHC, IF, IP, IHC (p), FACS 宿主: 小鼠 Monoclonal 9A1 unconjugated
anti-Replication Protein A2, 32kDa (RPA2) antibodyRPA2 适用: 人, 大鼠, 犬, 猴 WB, IHC, IF, IP, IHC (p), FACS 宿主: 小鼠 Monoclonal 1H10 unconjugated
anti-Replication Protein A2, 32kDa (RPA2) antibodyRPA2 适用: 人, 犬, 猴 WB, IHC, IF, IP, IHC (p), FACS 宿主: 小鼠 Monoclonal 7C12 unconjugated
anti-Replication Protein A2, 32kDa (RPA2) (AA 80-270) antibodyRPA2 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A2, 32kDa (RPA2) (AA 1-267) antibodyRPA2 适用: 人 WB, IHC, ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A2, 32kDa (RPA2) antibodyRPA2 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A2, 32kDa (RPA2) (N-Term) antibodyRPA2 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A2, 32kDa (RPA2) antibodyRPA2 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A2, 32kDa (RPA2) (AA 101-200) antibodyRPA2 适用: 小鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- RPA2 (Replication Protein A2, 32kDa (RPA2))
- 别名
- RPA2 (RPA2 产品)
- 别名
- REPA2 antibody, RPA32 antibody, 153194_at antibody, CG9273 antibody, Dmel\\CG9273 antibody, dRPA2 antibody, rpa antibody, zgc:109822 antibody, ik:tdsubc_2g1 antibody, xx:tdsubc_2g1 antibody, repa2 antibody, rpa32 antibody, RPA2 antibody, GB13976 antibody, LOC100230445 antibody, AA409079 antibody, AI325195 antibody, AU020965 antibody, RPA34 antibody, Rf-A2 antibody, replication protein A2 antibody, Replication protein A2 antibody, replication protein A2, 32kDa antibody, replication protein A 32 kDa subunit antibody, RPA2 antibody, Rpa2 antibody, rpa2 antibody, LOC725418 antibody, RPA2_2 antibody
- 背景
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Description: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
Gene: RPA2
- 分子量
- 35kDa
- 基因ID
- 6118
- UniProt
- P15927
- 途径
- Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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