ULK1 抗体 (pSer317)
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北京 101111
Quick Overview for ULK1 抗体 (pSer317) (ABIN6255203)
抗原
See all ULK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer317
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原理
- Phospho-ULK1 (Ser317) Antibody
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特异性
- Phospho-ULK(Ser317) Antibody detects endogenous levels of ULK.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
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免疫原
- A synthesized peptide derived from human ULK around the phosphorylation site of Ser317.
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亚型
- IgG
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anti-Unc-51 Like Kinase 1 (ULK1) (AA 951-1050) antibody
ULK1 适用: 人 WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Unc-51 Like Kinase 1 (ULK1) (AA 602-715) antibodyULK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H8 unconjugated
anti-Unc-51 Like Kinase 1 (ULK1) antibodyULK1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Unc-51 Like Kinase 1 (ULK1) (pSer556) antibodyULK1 适用: 人 WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Unc-51 Like Kinase 1 (ULK1) (pSer556) antibodyULK1 适用: 人 IF, DB 宿主: 兔 Polyclonal RB30585 unconjugated
anti-Unc-51 Like Kinase 1 (ULK1) (AA 567-577) antibody (Atto 390)ULK1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Atto 390
anti-Unc-51 Like Kinase 1 (ULK1) (AA 567-577) antibodyULK1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Unc-51 Like Kinase 1 (ULK1) (AA 567-577) antibody (Atto 594)ULK1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Atto 594
anti-Unc-51 Like Kinase 1 (ULK1) (AA 567-577) antibody (Atto 488)ULK1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Atto 488
anti-Unc-51 Like Kinase 1 (ULK1) (AA 567-577) antibody (Biotin)ULK1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal Biotin
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- ULK1 (Unc-51 Like Kinase 1 (ULK1))
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别名
- ULK1
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背景
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Description: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).
Gene: ULK1
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分子量
- 140-150 kDa
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基因ID
- 8408
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UniProt
- O75385
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途径
- Regulation of Cell Size, Autophagy
抗原
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